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Chemical Irritants The nucleus of the disk contains high levels of phospholipase A2 (PLA2) which initiates the inflammatory cascade Other inflammatory mediators include prostaglandins, leukotrienes, histamine, and bradykinin, which act as inflammatory and immune mediators Previous slide Next slide Back to first slide View graphic version © 1998 Specialty Physicians Alliance. All rights reserved. If you have questions or comments please contact webmaster@spa-ortho.com