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How Many Injections? Generally accepted that no further injections need to be performed in the same area if the first injection was not beneficial. If the initial response is favorable, but short lived, a second injection is reasonable. A maximum of 3 epidural injections per year is generally reported. Spacing - varies from days to weeks generally for a series of injections. Previous slide Next slide Back to first slide View graphic version © 1998 Specialty Physicians Alliance. All rights reserved. If you have questions or comments please contact webmaster@spa-ortho.com